PARTICLE, a Triplex-Forming Long ncRNA, Regulates Locus-Specific Methylation in Response to Low-Dose Irradiation

In BriefO'Leary et al. find a long non-coding RNA called PARTICLE that is overexpressed following irradiation.PARTICLE represses a tumor suppressor MAT2A via triplex formation and interaction with the polycomb repressor complex.PARTICLE also acts as a cytosolic scaffold for MAT2A in preparation for exosomal transport from the cell.