Palladium‐Catalyzed Cross‐Coupling Reactions of Diazine N‐Oxides with Aryl Chlorides, Bromides, and Iodides

New aspects of N-oxides: Pyrazine, pyridazine, and pyrimidine N-oxides are regioselectively arylated with aryl iodides, bromides, and chlorides in the presence of a palladium catalyst (see scheme). The resulting products can be deoxygenated in high yield or further functionalized by making use of the N-oxide functionality. FG=functional group.