吻素
神经激肽B
强啡肽
内分泌学
内科学
弓状核
弧(几何)
促黄体激素
生物
促性腺激素释放激素
正中隆起
下丘脑
强啡肽A
促性腺激素
神经肽
受体
P物质
激素
阿片肽
医学
类阿片
几何学
数学
作者
Víctor M. Navarro,Michelle L. Gottsch,Charles Chavkin,Hiroaki Okamura,Donald K. Clifton,Robert A. Steiner
标识
DOI:10.1523/jneurosci.1569-09.2009
摘要
Kisspeptin is encoded by the Kiss1 gene, and kisspeptin signaling plays a critical role in reproduction. In rodents, kisspeptin neurons in the arcuate nucleus (Arc) provide tonic drive to gonadotropin-releasing hormone (GnRH) neurons, which in turn supports basal luteinizing hormone (LH) secretion. Our objectives were to determine whether preprodynorphin (Dyn) and neurokinin B (NKB) are coexpressed in Kiss1 neurons in the mouse and to evaluate its physiological significance. Using in situ hybridization, we found that Kiss1 neurons in the Arc of female mice not only express the Dyn and NKB genes but also the NKB receptor gene (NK3) and the Dyn receptor [the kappa opioid receptor (KOR)] gene. We also found that expression of the Dyn, NKB, KOR, and NK3 in the Arc are inhibited by estradiol, as has been established for Kiss1, and confirmed that Dyn and NKB inhibit LH secretion. Moreover, using Dyn and KOR knock-out mice, we found that long-term disruption of Dyn/KOR signaling compromises the rise of LH after ovariectomy. We propose a model whereby NKB and dynorphin act autosynaptically on kisspeptin neurons in the Arc to synchronize and shape the pulsatile secretion of kisspeptin and drive the release of GnRH from fibers in the median eminence.
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