氧化应激
疾病
神经科学
τ蛋白
氧化磷酸化
病态的
阿尔茨海默病
淀粉样蛋白(真菌学)
退行性疾病
医学
病理
化学
生物
生物化学
内科学
标识
DOI:10.2174/09298673113206660258
摘要
Alzheimer´s disease (AD) is a neurodegenerative disorder with no known cure and rapid rise in incidence. The predominant cognitive impairment is currently treated using cognitive enhancers like cholinesterase inhibitors. The two molecular hallmarks of AD are amyloid plaques created from an amyloid precursor protein and hyperphosphorylated tau protein that is deposited as neurofibrillary tangles inside neurons. A number of pathological mechanisms follow or precede these formations. Alteration in mitochondrial function and deposition of heavy metals are reported. The disease progression is enhanced by oxidative stress. However, the role of oxidative stress is not universally accepted. The current review covers and discusses the basic evidence and role of oxidative stress in AD development.
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