医学
牙龈肿大
氨氯地平
基因型
基因多态性
多重耐药
内科学
基因
多态性(计算机科学)
作者
Kumaraswamy Lr Naik,Kapil Jhajharia,Roopam Chaudhary,Aravind Tatikonda,Aprinderpal Singh Dhaliwal,Rose Kanwaljeet Kaur
标识
DOI:10.4103/0972-124x.145837
摘要
Gingival enlargement comprises any clinical condition in which an increase in the size of the gingiva is observed. It is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. Among calcium channel blockers, nifedipine causes gingival enlargement in about 10% of patients, whereas the incidence of amlodipine, a third-generation calcium channel blocker, induced gingival enlargement is very limited. Because the calcium antagonists, albeit to a variable degree, act as inhibitors of P-glycoprotein (P-gp), the gene product of multidrug resistance 1 (MDR1), and inflammation may modify P-gp expression. We hereby, report a case of amlodipine-induced gingival enlargement with MDR1 3435C/T polymorphism, associated with inflammatory changes due to plaque accumulation, in a 50-year-old hypertensive male patient. The genotype obtained for the polymorphism was a heteromutant genotype, thus supporting the contention that the MDR1 polymorphism may alter the inflammatory response to the drug.
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