脂联素
生物标志物
背景(考古学)
疾病
医学
糖尿病
炎症
内科学
药品
2型糖尿病
内分泌学
胰岛素抵抗
生物信息学
药理学
生物
古生物学
生物化学
作者
Shoba Shetty,Christine M. Kusminski,Philipp E. Scherer
标识
DOI:10.1016/j.tips.2009.02.004
摘要
Adiponectin is a secretory protein predominantly expressed by adipocytes and released at a high rate into circulation. The ease with which the levels of adiponectin can be measured owing to its high abundance, small diurnal variation and high stability in plasma have made it a popular target for measurements in many clinical studies. It has emerged as a valuable biomarker for insulin sensitivity, cardiovascular risk and inflammation. However, adiponectin levels have been measured in many additional disease states. Preclinical studies not only have implicated adiponectin as an outstanding biomarker but also have demonstrated direct cardio-protective and insulin-sensitizing properties to be associated with the protein. Adiponectin might, therefore, be a viable protein therapeutic that could be supplied in a recombinant form in the context of type 2 diabetes and cardiovascular disease. However, the high abundance, complex tertiary and quaternary structure and rapid turnover might make chronic administration of the protein rather challenging.
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