西马嗪
阿特拉津
化学
固体脂质纳米粒
Zeta电位
杀虫剂
色谱法
粒径
纳米颗粒
动力学
细胞毒性
环境化学
体外
生物化学
纳米技术
农学
材料科学
生物
物理
物理化学
量子力学
作者
Jhones Luiz de Oliveira,Estefânia Vangelie Ramos Campos,Camila Morais Gonçalves da Silva,Tatiane Pasquoto,Renata de Lima,Leonardo Fernandes Fraceto
摘要
Solid lipid nanoparticles (SLN) containing the herbicides atrazine and simazine were prepared and characterized, and in vitro evaluation was made of the release kinetics, herbicidal activity, and cytotoxicity. The stability of the nanoparticles was investigated over a period of 120 days, via analyses of particle size, ζ potential, polydispersion, pH, and encapsulation efficiency. SLN showed good physicochemical stability and high encapsulation efficiencies. Release kinetics tests showed that use of SLN modified the release profiles of the herbicides in water. Herbicidal activity assays performed with pre- and postemergence treatment of the target species Raphanus raphanistrum showed the effectiveness of the formulations of nanoparticles containing herbicides. Assays with nontarget organisms (Zea mays) showed that the formulations did not affect plant growth. The results of cytotoxicity assays indicated that the presence of SLN acted to reduce the toxicity of the herbicides. The new nanoparticle formulations enable the use of smaller quantities of herbicide and therefore offer a more environmentally friendly method of controlling weeds in agriculture.
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