The Relationship Between Lower Urinary Tract Symptom Severity and Sleep Disturbance in the CAMUS Trial

No AccessJournal of UrologyAdult Urology1 Jun 2011The Relationship Between Lower Urinary Tract Symptom Severity and Sleep Disturbance in the CAMUS Trial Brian T. Helfand, Kevin T. McVary, Sreelatha Meleth, Victoria Sharp, Harris Foster, Michael Naslund, O. Dale Williams, and CAMUS Study Group Brian T. HelfandBrian T. Helfand Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois , Kevin T. McVaryKevin T. McVary Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois , Sreelatha MelethSreelatha Meleth Division of Preventive Medicine, University of Alabama, Birmingham, Alabama , Victoria SharpVictoria Sharp Department of Urology, University of Iowa, Iowa City, Iowa , Harris FosterHarris Foster Department of Urology, Yale University School of Medicine, New Haven, Connecticut , Michael NaslundMichael Naslund Department of Urology, University of Maryland, Baltimore, Maryland , O. Dale WilliamsO. Dale Williams Division of Preventive Medicine, University of Alabama, Birmingham, Alabama , and CAMUS Study Group View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.012AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Bothersome lower urinary tract symptoms, including nocturia, significantly impact general health related quality of life in men, as does sleep disturbance. However, few groups have examined the relationship between urinary symptom severity and sleep disturbance. Materials and Methods: Men enrolled in a clinical trial of saw palmetto (Serenoa repens) were studied at baseline. Lower urinary tract symptom severity, as determined by the American Urological Association symptom index and quality of life scores, and the degree of sleep disturbance were determined by the Jenkins sleep scale. Analysis was done, adjusting for baseline characteristics, to identify predictors of severe sleep disturbance. Results: A total of 366 men with a mean ± SD age of 60.9 ± 8.3 years who had moderate-severe lower urinary tract symptoms (mean American Urological Association symptom index score 14.58 ± 4.6 points) and a mean Jenkins sleep score of 7.3 ± 4.7 points were included in analysis. Overall there were significant associations between the American Urological Association symptom index score and sleep disturbance severity. Multivariate analysis revealed that obstructive and irritative symptoms were significantly associated with severe sleep disturbance. Further analysis showed that lower serum prostate specific antigen and post-void residual urine volume were also significantly associated with the degree of sleep disturbance. Conclusions: Lower urinary tract symptom severity is a risk factor for severe sleep disturbance in men. 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Google Scholar © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byHelfand B, Smith A, Lai H, Yang C, Gore J, Erickson B, Kreder K, Cameron A, Weinfurt K, Griffith J, Lentz A, Talaty P, Andreev V and Kirkali Z (2018) Prevalence and Characteristics of Urinary Incontinence in a Treatment Seeking Male Prospective Cohort: Results from the LURN StudyJournal of Urology, VOL. 200, NO. 2, (397-404), Online publication date: 1-Aug-2018.Fantus R, Packiam V, Wang C, Erickson B and Helfand B (2018) The Relationship between Sleep Disorders and Lower Urinary Tract Symptoms: Results from the NHANESJournal of Urology, VOL. 200, NO. 1, (161-166), Online publication date: 1-Jul-2018.Branche B, Howard L, Moreira D, Roehrborn C, Castro-Santamaria R, Andriole G, Hopp M and Freedland S (2017) Sleep Problems are Associated with Development and Progression of Lower Urinary Tract Symptoms: Results from REDUCEJournal of Urology, VOL. 199, NO. 2, (536-542), Online publication date: 1-Feb-2018.Chandrapal J, Bowen R, Patel D, Le A, Hotaling J and Southwick A (2016) High Rates of Inadequate Urine Volume Cause Failure of Clinic Based Uroflowmetry in Men with Lower Urinary Tract SymptomsUrology Practice, VOL. 3, NO. 4, (247-250), Online publication date: 1-Jul-2016.Kupelian V, Araujo A, Wittert G and McKinlay J (2014) Association of Moderate to Severe Lower Urinary Tract Symptoms with Incident Type 2 Diabetes and Heart DiseaseJournal of Urology, VOL. 193, NO. 2, (581-586), Online publication date: 1-Feb-2015.Araujo A, Yaggi H, Yang M, McVary K, Fang S and Bliwise D (2013) Sleep Related Problems and Urological Symptoms: Testing the Hypothesis of Bidirectionality in a Longitudinal, Population Based StudyJournal of Urology, VOL. 191, NO. 1, (100-106), Online publication date: 1-Jan-2014. Volume 185Issue 6June 2011Page: 2223-2228 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.Keywordsurination disordersprostatesleeppermixonprostatic hyperplasiaAcknowledgmentsJoseph J. Veilleux, Rottapharm/Madaus, provided saw palmetto fruit extract and placebo. Dr. John W. Kusek, National Institute of Diabetes, Digestive and Kidney Diseases, Drs. Catherine M. Meyers and Sheila Caldwell, National Center for Complementary and Alternative Medicine, and Drs. Joseph M. Betz and Paul M. Coates, Office of Dietary Supplements, National Institutes of Health, assisted with the study.MetricsAuthor Information Brian T. Helfand Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois More articles by this author Kevin T. McVary Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois More articles by this author Sreelatha Meleth Division of Preventive Medicine, University of Alabama, Birmingham, Alabama More articles by this author Victoria Sharp Department of Urology, University of Iowa, Iowa City, Iowa More articles by this author Harris Foster Department of Urology, Yale University School of Medicine, New Haven, Connecticut More articles by this author Michael Naslund Department of Urology, University of Maryland, Baltimore, Maryland Financial interest and/or other relationship with Glaxo. More articles by this author O. Dale Williams Division of Preventive Medicine, University of Alabama, Birmingham, Alabama More articles by this author CAMUS Study Group More articles by this author Expand All Advertisement PDF downloadLoading ...