化学
乙腈
色谱法
亲水作用色谱法
极地的
水溶液
化学极性
高效液相色谱法
有机化学
分子
物理
天文
作者
Mariana R. Gama,Raquel Gomes da Costa Silva,Carol H. Collins,Carla Beatriz Grespan Bottoli
标识
DOI:10.1016/j.trac.2012.03.009
摘要
In the early 1990s, hydrophilic interaction (liquid) chromatography (HILIC) emerged as a new separation method. HILIC is becoming increasingly popular for the separation of polar compounds in aqueous-organic mobile phases rich in organic solvents (usually acetonitrile). It has become important for the separation of pharmaceuticals, neurotransmitters, nucleosides, nucleotides and other compounds. This review presents an overview of HILIC separation systems, comparing it to several other recently described modes.
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