Fabrication and evaluation of a novel polymeric hydrogel of carboxymethyl chitosan-g-polyacrylic acid (CMC-g-PAA) for oral insulin delivery

The CMC-g-PAA hydrogels could release INS in alkaline environment (i.e. intestinal), specifically. This method could prevent IND from destroying by pepsase. Therefore, the CMC-g-PAA hydrogel had a potential application on the oral delivery of protein drugs.