Aim: To check the embryo toxicity, acute toxicity and accumulation toxicity of matter extracted from the pulp of cornus by ethanol. Methods: Acute toxicity test,accumulation toxicity test and teratogenicity test were used in this study.Results: LD_ 50 10 g/kg ,accumulation coefficient 5,and the matter extracted from the pulp of cornus by ethanol had no embryotoxicity on the embryos of rats.Conclusion:The matter extracted from the pulp of cornus by ethanol has no acute toxicity, accumulation toxicity and embryotoxicity.