Synthesis and Herbicidal Activity of Saflufenacil

Saflufenacil is a new kind of herbicide with excellent herbicidal actiity.The aim is to study its synthesis,analysis method and evaluate herbicidal activity.[Methods] methyl 5-amino-2-chloro-4-fluorobenzoate(5) was produced from 2-chloro-4-fluorobenzoic acid by esterification,nitration and reduction,then reacted with triphosgene to give methyl 2-chloro-4-fluoro-5-isocyanatobenzoate(6),6 was cyclized with ethyl 3-amino-4,4,4-trifluorobut-2-enoate,then methylated,followed by hydrolysis to obtain 2-chloro-5-(2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)-4-fluorobenzoic acid(10),which was reacted with N-methyl-N-isopropyl sulfamide to give target compound.[Results] Overall yield was 6.26%.The chemical structures were confirmed by 1H NMR,IR and MS.Purity was 99.8% by HPLC analysis.[Conclusions] The herbicidal activities of the target compound and purchased saflufenacil were compared.And the same results were obtained