Effects of Ginaton on expressions of Fas and Bcl-2 protein in rats with cerebral ischemia reperfusion injury

Objective To explore the protective effects of Ginaton on cerebral ischemia reperfusion injury and its influence on the exprssions of Fas and Bcl 2 protein in rats. Methods The global cerebral ischemia reperfusion model was established to investigate the expressions of Fas and Bcl 2 protein and the changes after given Ginaton were observed with immunochemistry technique. Results The expression of Fas protein appeared in simple ischemic group and reperfusion 3 hours group, and peaked 6 hours after reperfusion ,and decreased 24 hours after reperfusion. The expression of Bcl 2 peaked 3 hours after reperfusion, and gradually decreased 6 hours after reperfusion, and its expression reduced obviously 24 hours after reperfusion.In Ginaton group, the expression of Fas protein obviously decreased and Bcl 2 protein increased at corresponding time. Conclusion Ginaton can reduce the apoptosis following cerebral ischemia reperfusion and has protective effect on the injury of ischemia and reperfusion.