Expression of TRA1 mRNA in hepatocellular carcinoma and liver cirrhosis tissue

Objective To investigate the expression and relationship of TRA1 mRNA among hepatocellular carcinoma,liver cirrhosis and normal liver tissues. Methods RT-PCR was used to detect the expression of TRA1 mRNA in 34specimens of hepatocellular carcinoma,liver cirrhosis and normal liver tissues. Results The expression rates of TRA1in hepatocellular carcinoma,liver cirrhosis and normal liver tissues were 95. 00%,84. 21% and 50. 00%,respectively,there were significant differences between hepatocellular carcinoma and normal liver tissues(P 0. 05),but no significant differences between liver cirrhosis and normal liver tissues(P 0. 05). The expression levels of TRA1 mRNA were 1. 67 ± 0. 96,1. 49 ± 0. 53,0. 57 ± 0. 27,respectively,which was significantly higher in hepatocellular carcinoma and liver cirrhosis tissues than that in normal liver tissues(P 0. 05). Conclusion TRA1 mRNA is involved in the progression of hepatocellular carcinoma and liver cirrhosis,and it may be a potential biomarker for diagnosis and target for therapy.