Brain natriuretic peptide in the diagnosis of chronic heart failure

Objective:To investigate brain natriuretic peptide(NT-proBNP) levels value and significance in diagnosis of patients with chronic heart failure.Methods:Took quantitative immunofluorescence assay detect 35 cases chronic heart failure patients(study group 1) and 15 asymptomatic heart failure patients(study group 2) brain natriuretic peptide levels,and compared with 15 healthy adults(control group) .Results:The patients with heart failure,heart failure with healthy asymptomatic patients brain natriuretic peptide levels were(850.5±325.0) ,(434.3±135.7) and(112.3±29.4) ng/L,the difference between the two groups were statistically significant(P0.01);three groups of brain natriuretic peptide levels in 95% confidence interval,respectively were 767.9-925.6,368.0-520.4 and 93.1-119.8 ng/L;when brain natriuretic peptide levels for diagnosis of heart failure circles was 120 ng/L,the diagnostic sensitivity and specificity were 100% and 87.6%;cardiac function grade Ⅰ,Ⅱ grade,Ⅲ and Ⅳ grade level of brain natriuretic peptide levels were(429.8±129.6) ng/L,(638.7±237.5) ,(878.9±320.8) and(1 033.7±545.9) ng/L,there were significant difference between the various levels(P0.01);brain natriuretic peptide levels and cardiac function was positively correlated(r=0.823,P0.01) ,with primary disease not related(P 0.05) .Conclusion:Brain natriuretic peptide level in patients with chronic heart failure diagnosis has important clinical value.