Protective effects of baicalin on hepatic fibrosis in mice

OBJECTIVE To investigate the protective effect of baicalin against carbon tetrachloride( CCl4)-induced hepatic fibrosis in mice.METHODS The experimental model mice of hepatic fibrosis was induced by CCl4.The serum ALT/GPT,AST/GOT,AKP, hepatic hydroxyproline ( HYP) and liver,spleen and thymus index were determined.RESULTS Baicalin significantly reduced serum ALT/GPT,AST/GOT,AKP,HYP and liver index.CONCLUSION Baicalin has a protective effect on hepatic fibrosis induced by CCl4 in mice.