Clinical study of midazolam combined with sufentanil for sedation during spinal anesthesia in elderly patients

【Objective】To observe the optimal dose of midazolam combined with sufentanil for sedation in elderly patients during spinal anesthesia.【Methods】80 ASA I-Ⅲ patients were randomly assigned into the following groups: group I(S0.1,M10),groupⅡ(S0.1,M30),group Ⅲ(S0.15,M20),group Ⅳ(S0.2,M10).OAA/S score,amnesia,hemodynamic and respiratory changes,the adverse reactions were recorded.【Results】SBP,DBP,HR,SpO2 of the 4 group decreased in normal range,SpO2 of group Ⅳ 5 min,10 min after receiving sedative was lower than that of the other groups(P 0.05);OAA/S score of group Ⅱ 5 min,10 min after receiving sedative was lower than that of the other groups(P 0.05);amnesia of group Ⅱ was 50%.【Conclusion】30μg/kg midazolam combined with 0.1μg/ kg sufentanil was the optimal dose for sedation in elderly patients during spinal anesthesia.