The change of serum vaspin level in elderly type 2 diabetic patients with nonalcoholic fatty liver disease

Objective To investigate the changes of serum vaspin levels in elderly type 2 diabetic patients with nonalcoholic fatty liver disease and its clinical significance.Methods The serum level of vaspin was measured in 44 elderly type 2 diabetic patients with nonalcoholic fatty liver disease(T2DM+ NAFLD group),40 elderly type 2 diabetic patients without nonalcoholic fatty liver disease(T2DM group), 40 elderly normal glucose tolerance patients with nonalcoholic fatty liver disease(NAFLD group) and 41 elderly normal glucose tolerance patients without nonalcoholic fatty liver disease(normal control,NC group) by enzyme-linked immunosorbent assay simultaneously.The visceral fat thickness(VFT) was measured with high freguency ultrasound.Results(1)The serum levels of vaspin in T2DM+NAFLD group,T2DM group and NAFLD group were significantly higher than those in NC group[(1.46±0.43, 1.03±0.27,0.76±0.28 vs 0.36±0.13) ng/ml,P0.01,P0.01,P0.05,respectively],respectively. (2)Multiple stepwise regression analysis showed FIns,VFT and HbA_1c level were independent foctors influensing vaspin level.Vaspin,VFT and TG were positively correlated with nonalcoholic fatty liver disease in elderly type 2 diabetes.Conclusions The change of serum vaspin level may partly play a role in the pathogenesis and development of elderly type 2 diabetes complicated nonalcoholic fatty liver disease.