Objective To observe the wrinkle reducing effect of Nlite Laser when used together with Botulinum Toxin.Methods Nlite Laser treated the wrinkle site,and then the Botulinum Toxin was injected into the markpoint near the wrinkle.Results A 1~2 year followed-up of sixty-one patients showed satisfactory results.The satisfactory rate and effective rate were 90.5% and 98%,respectively.Conclusion Combined use of Nlite Laser and Botulinum Toxin for wrinkle reduction has a promising future in cosmetic surgery.