笔记本电脑
瓶颈
计算机科学
RNA序列
核糖核酸
概率逻辑
计算生物学
生物
算法
人工智能
遗传学
基因
转录组
基因表达
操作系统
嵌入式系统
作者
Nicolas Bray,Harold Pimentel,Páll Melsted,Lior Pachter
摘要
We present kallisto, an RNA-seq quantification program that is two orders of magnitude faster than previous approaches and achieves similar accuracy. Kallisto pseudoaligns reads to a reference, producing a list of transcripts that are compatible with each read while avoiding alignment of individual bases. We use kallisto to analyze 30 million unaligned paired-end RNA-seq reads in <10 min on a standard laptop computer. This removes a major computational bottleneck in RNA-seq analysis.
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