Discovery of novel skeletons of aphid repellents based on the key fragment of nepetalactone and plant volatiles

The introduction of novel structures such as compounds IV-30 and IV-36 based on nepetalactone and plant volatile fragments resulted in the discovery of novel promising para-pheromones for aphid control. These compounds exhibit stable and effective repellent activities, providing a solid foundation for further development of synthetic aphid repellents in integrated pest management strategies. © 2025 Society of Chemical Industry.