Microbial degradation mechanisms, degradation pathways, and genetic engineering for pyrethroids: current knowledge and future perspectives

Pyrethroids are synthetic products derived from natural pyrethroids present in flowers and are extensively used as pesticides for agriculture, animal husbandry, and household pest control. However, excessive and prolonged usage of pyrethroid insecticides can result in adverse effects on both non-target and target species. Therefore, effective technologies need to be developed to remove pyrethroid contamination and ensure environmental safety. Microbial remediation of various pesticide contaminants is highly practicable, low cost, and eco-friendly compared to physical and chemical methods. Different microbiota are screened to eliminate or degrade the contaminants. Microbial remediation technology utilizes the natural ability of microbiota to treat contaminated areas. Previous studies have mostly focused on the isolation and screening of microorganisms for pyrethroid biodegradation, as well as on the kinetics and pathways of pyrethroid biodegradation. In order to develop effective bioremediation strategies, further research based on molecular biology and bioengineering is required for a comprehensive exploration of pyrethroid-degrading microorganisms. To date, the microbial degradation of pyrethroid pesticides and the underlying mechanisms have been rarely reviewed. Therefore, this critical review encompasses the latest knowledge on synthetic pyrethroids from structural properties, bio-toxicity, and characterization of microbial degradation strains to degradation characteristics, intrinsic mechanisms, and microbial degradation pathways. The future of microbial remediation depends on combining advanced gene technology with traditional bioremediation methods to sustainably degrade pesticide contaminants. It also summarizes the factors affecting degradation efficiency and concludes with prospects, along with current challenges and limitations.