活性氧
清除
缺血
急性肾损伤
肾
化学
氧气
再灌注损伤
纳米颗粒
细胞生物学
生物物理学
药理学
生物化学
医学
抗氧化剂
生物
纳米技术
内科学
材料科学
有机化学
作者
Wenxiang Feng,Nan Zhu,Yubin Xia,Zehai Huang,Jianmin Hu,Zhiqiang Guo,Yuzhu Li,Song Zhou,Yongguang Liu,Ding Liu
出处
期刊:iScience
[Elsevier]
日期:2024-03-01
卷期号:: 109504-109504
标识
DOI:10.1016/j.isci.2024.109504
摘要
Kidney transplantation is essential for patients with end-stage renal disease; however, ischemia-reperfusion injury (IRI) during transplantation can lead to acute kidney damage and compromise survival. Recent studies have reported that antiferroptotic agents may be a potential therapeutic strategy, by reducing production of reactive oxygen species (ROS). Therefore, we constructed rutin-loaded polydopamine nanoparticles (PEG-PDA@rutin NPs, referred to as PPR NPs) to eliminate ROS resulting from IRI. Physicochemical characterization showed that the PPR NPs were ∼100 nm spherical particles with good ROS scavenging ability. Notably, PPR NPs could effectively enter lipopolysaccharide (LPS)-treated renal tubular cells, then polydopamine (PDA) released rutin to eliminate ROS, repair mitochondria, and suppress ferroptosis. Furthermore, in vivo imaging revealed that PPR NPs efficiently accumulated in the kidneys after IRI and effectively protected against IRI damage. In conclusion, PPR NPs demonstrated an excellent ability to eliminate ROS, suppress ferroptosis, and protect kidneys from IRI.
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