Garcimultiflins A–C, unusual polycyclic polyprenylated acylphloroglucinols from the pericarps of Garcinia multiflora as interleukin-1β and pyroptosis inhibitors

Garcimultiflins A–C (1–3), three PPAPs with unusual skeletons, were isolated from the pericarps of Garcinia multiflora . Compound 2 blocks the secretion of IL-1β through suppressing the activation of NLRP3 inflammasome in THP-1 macrophages.