化学
DNA
组合化学
异吲哚啉
碱基
组分(热力学)
立体化学
生物化学
有机化学
物理
热力学
作者
Yandan Bao,Xing Ming,Naylor Matthew,Xiao-Hua Chen,Xuan Wang,Xiaojie Lu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-06-29
卷期号:26 (14): 2763-2767
被引量:3
标识
DOI:10.1021/acs.orglett.3c01817
摘要
While DNA-encoded macrocyclic libraries have gained substantial attention and several hit compounds have been identified from DNA-encoded library technology, efficient on-DNA macrocyclic methods are also required to construct DNA-linked libraries with a high degree of cyclization and DNA integrity. In this paper, we reported a set of on-DNA methodologies, including the use of an OPA-mediated three-component cyclization with native handles of amino acids and photoredox chemistries. These chemistries proceed smoothly under mild conditions in good to excellent conversions, successfully generating novel isoindole, isoindoline, indazolone, and bicyclic scaffolds.
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