小RNA
基因沉默
生物发生
生物
计算生物学
疾病
心理压抑
基因表达调控
小RNA
生物信息学
基因
基因表达
遗传学
医学
病理
作者
Anchal Vishnoi,Sweta Rani
出处
期刊:Methods in molecular biology
日期:2022-11-29
卷期号:: 1-12
被引量:30
标识
DOI:10.1007/978-1-0716-2823-2_1
摘要
MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and translational repression by binding to the target mRNAs. Since it was discovered in 1993, miRNA is found in all eukaryotic cells conserved across the species. miRNA-size molecules are also known to be found in prokaryotes. Regulation of miRNAs is extensively studied for their role in biological processes as well as in development and progression of various human diseases including neurodegenerative diseases, cardiovascular disease, and cancer. miRNA-based therapy has a promising application, and with a good delivery system, miRNA therapeutics can potentially be a success. miRNAs and EVs have potential therapeutic and prognostic application in a range of disease models. This chapter summarizes miRNA biogenesis and explores their potential roles in a variety of diseases. miRNAs hold huge potential for diagnostic and prognostic biomarkers and as predictors of drug response.
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