利格列汀
析因实验
分式析因设计
实验设计
中心组合设计
工艺优化
过程开发
设计质量
产量(工程)
过程(计算)
制造工程
工艺设计
计算机科学
工艺工程
色谱法
材料科学
响应面法
工程类
化学
化学工程
医学
数学
过程集成
复合材料
粒径
内分泌学
机器学习
糖尿病
操作系统
2型糖尿病
统计
作者
Hailong Wang,Kai Chen,Biyue Lin,Jingping Kou,Lijun Li,S. X. Wu,Shouzhu Liao,Guodong Sun,Junwen Pu,Hua Ye,Zhongqing Wang
标识
DOI:10.1021/acs.oprd.2c00230
摘要
A design of experiments (DoE) approach was applied to the development and optimization of the manufacturing process to prepare linagliptin. DoE techniques such as a central composite face-centered design and a fractional factorial design were applied to obtain the critical process parameters and establish the optimal reaction conditions. With process-related impurities determined and successfully removed, a robust high-yielding and high-purity procedure was identified, which has been successfully demonstrated at a 100 g scale level to prepare the desired product in a 68% overall isolated yield and high-performance liquid chromatography (HPLC) purity of around 99.9%.
科研通智能强力驱动
Strongly Powered by AbleSci AI