材料科学
导电体
电极
生物相容性材料
流变学
制作
导电聚合物
纳米技术
挤压
3D打印
组织工程
墨水池
复合数
复合材料
聚合物
生物医学工程
化学
医学
替代医学
物理化学
病理
作者
Ji‐Hwan Kim,Jinah Jang
出处
期刊:International Journal of bioprinting
[Whioce Publishing Pte Ltd.]
日期:2022-11-16
卷期号:9 (1): 643-643
被引量:1
标识
DOI:10.18063/ijb.v9i1.643
摘要
Native tissues are affected by the microenvironment surrounding the tissue, including electrical activities. External electrical stimulation, which is used in replicating electrical activities and regulating cell behavior, is mainly applied in neural and cardiac tissues due to their electrophysiological properties. The in vitro cell culture platform with electrodes provides precise control of the stimulation property and eases the observation of the effects on the cells. The frequently used electrodes are metal or carbon rods, but their risk of damaging tissue and their mechanical properties that are largely different from those of native tissues hinder further applications. Biocompatible polymer reinforced with conductive fillers emerges as a potential solution to fabricate the complex structure of the platform and electrode. Conductive polymer can be used as an ink in the extrusion-based printing method, thus enabling the fabrication of volumetric structures. The filler simultaneously alters the electrical and rheological properties of the ink; therefore, the amount of additional compound should be precisely determined regarding printability and conductivity. This review provides an overview on the rheology and conductivity change relative to the concentration of conductive fillers and the applications of printed electrodes. Next, we discuss the future potential use of a cell culture platform with electrodes from in vitro and in vivo perspectives.
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