巢状曲霉
二酮哌嗪
曲霉
异源的
微生物学
异源表达
色氨酸
富马西林
生物
生物化学
化学
立体化学
遗传学
基因
血管生成
重组DNA
氨基酸
突变体
作者
Cory B. Jenkinson,Shu-Yi Lin,Miguel Villarreal,C. Elizabeth Oakley,David H. Sherman,Chin‐Cheng Lee,Clay C. C. Wang,Berl R Oakley
标识
DOI：10.1021/acs.jnatprod.4c00113
摘要
Fungal secondary metabolite (SM) biosynthetic gene clusters (BGCs) containing dimethylallyltryptophan synthases (DMATSs) produce structurally diverse prenylated indole alkaloids with wide-ranging activities that have vast potential as human therapeutics. To discover new natural products produced by DMATSs, we mined the Department of Energy Joint Genome Institute's MycoCosm database for DMATS-containing BGCs. We found a DMATS BGC in
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