Constructing multifunctional Cu Single-Atom nanozyme for synergistic nanocatalytic Therapy-Mediated Multidrug-Resistant bacteria infected wound healing

过氧亚硝酸盐 活性氮物种 活性氧 化学 过氧化氢 细菌 过氧化氢酶 伤口愈合 一氧化氮 超氧化物 微生物学 生物化学 生物 免疫学 有机化学 遗传学
作者
Xiaochen Qiu,Liang Zhuang,Jian Yuan,Huizhen Wang,Xiaoyu Dong,Shan He,Shanyue Guan,Zhiyue Chang,Pengtao Bao
出处
期刊:Journal of Colloid and Interface Science [Elsevier BV]
卷期号:652: 1712-1725 被引量:12
标识
DOI:10.1016/j.jcis.2023.08.192
摘要

Developing an effective strategy to combat multi-drug-resistant (MDR) bacteria and promote wound healing without overuse of antibiotics remains an important and challenging goal. Herein, we established a synergistic reactive oxygen species (ROS) and reactive nitrogen species (RNS)-mediated nanocatalytic therapy, which was consisted of a multifunctional Cu single-atom nanozyme loaded with the l-arginine (l-Arg@Cu-SAzymes) and a low level of hydrogen peroxide (H2O2) as a trigger. l-Arg@Cu-SAzymes can possess excellent dual enzyme-like activities: catalase (CAT)-like activity that decompose H2O2 into O2, and subsequent oxidase (OXD)-like activity that convert O2 to cytotoxic superoxide anion radical (•O2-). Meanwhile, l-Arg@Cu-SAzymes can also be triggered by H2O2 to release nitric oxide (NO), which can continue to react with •O2- to generate more lethal peroxynitrite (ONOO-). Collectively, the synergistic ROS and RNS mediated by l-Arg@Cu-SAzymes endow the treatment system with an outstanding antibacterial ability against MDR bacteria and reduce the inflammation at the wound site. Furthermore, l-Arg@Cu-SAzymes-mediated NO and O2 release promote the cell proliferation, collagen synthesis, and the angiogenesis, as well as facilitate macrophage polarization to reparative M2 phenotype, thereby accelerating wound closure and tissue remodeling. Therefore, l-Arg@Cu-SAzymes-based synergistic nanocatalytic therapy can be regarded as a promising strategy for MDR bacterial infected wounds treatment, owing to their potent antibacterial efficacy and enhanced tissue remodeling effects.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
6秒前
我不爱池鱼应助breath采纳,获得10
9秒前
多情凝荷完成签到 ,获得积分10
11秒前
补药完成签到,获得积分10
12秒前
leiiiiiiii完成签到,获得积分10
13秒前
浅色墨水完成签到,获得积分10
13秒前
YamDaamCaa应助wnche采纳,获得260
17秒前
华仔应助补药采纳,获得10
18秒前
MingQue完成签到,获得积分10
23秒前
jenningseastera完成签到,获得积分0
24秒前
28秒前
Ammr完成签到 ,获得积分10
28秒前
29秒前
充电宝应助liu采纳,获得10
29秒前
懵懂的雪糕完成签到 ,获得积分10
29秒前
ljx完成签到 ,获得积分10
31秒前
可爱的函函应助zifeimo采纳,获得10
32秒前
阳光沛柔发布了新的文献求助30
32秒前
赘婿应助踏山河采纳,获得10
35秒前
pluto应助ShengzhangLiu采纳,获得10
36秒前
37秒前
晴空万里完成签到,获得积分10
39秒前
Zsx关闭了Zsx文献求助
40秒前
OGB应助zhhr采纳,获得10
40秒前
41秒前
所所应助自觉竺采纳,获得10
41秒前
42秒前
科研通AI2S应助breath采纳,获得10
42秒前
怕孤单的山河完成签到 ,获得积分10
43秒前
46秒前
47秒前
qks完成签到 ,获得积分0
48秒前
48秒前
踏山河发布了新的文献求助10
48秒前
49秒前
49秒前
50秒前
Timber发布了新的文献求助30
51秒前
薄灯男孩发布了新的文献求助10
51秒前
刘明生发布了新的文献求助10
52秒前
高分求助中
(禁止应助)【重要!!请各位详细阅读】【科研通的精品贴汇总】 10000
Semantics for Latin: An Introduction 1099
Biology of the Indian Stingless Bee: Tetragonula iridipennis Smith 1000
Robot-supported joining of reinforcement textiles with one-sided sewing heads 700
Thermal Quadrupoles: Solving the Heat Equation through Integral Transforms 500
SPSS for Windows Step by Step: A Simple Study Guide and Reference, 17.0 Update (10th Edition) 500
PBSM: Predictive Bi-Preference Stable Matching in Spatial Crowdsourcing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4126261
求助须知:如何正确求助?哪些是违规求助? 3663827
关于积分的说明 11593227
捐赠科研通 3363465
什么是DOI,文献DOI怎么找? 1848222
邀请新用户注册赠送积分活动 912232
科研通“疑难数据库(出版商)”最低求助积分说明 827935