肺结核
结核分枝杆菌
药品
医学
抗药性
重症监护医学
生物
药理学
微生物学
病理
作者
Ankit Verma,Bindu Naik,Vijay Kumar,Sadhna Mishra,Megha Choudhary,Javed Masood Khan,Arun Kumar Gupta,Piyush Pandey,Sarvesh Rustagi,Barnali Kakati,Sanjay Gupta
出处
期刊:ACS Infectious Diseases
[American Chemical Society]
日期:2023-11-09
卷期号:9 (12): 2369-2385
标识
DOI:10.1021/acsinfecdis.3c00436
摘要
Tuberculosis (TB) is a global health threat that causes significant mortality. This review explores chemotherapeutics that target essential processes in Mycobacterium tuberculosis, such as DNA replication, protein synthesis, cell wall formation, energy metabolism, and proteolysis. We emphasize the need for new drugs to treat drug-resistant strains and shorten the treatment duration. Emerging targets and promising inhibitors were identified by examining the intricate biology of TB. This review provides an overview of recent developments in the search for anti-TB drugs with a focus on newly validated targets and inhibitors. We aimed to contribute to efforts to combat TB and improve therapeutic outcomes.
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