黑色素瘤
MAPK/ERK通路
癌症研究
合成致死
生物
表观遗传学
威罗菲尼
靶向治疗
程序性细胞死亡
癌症
DNA修复
细胞凋亡
细胞生物学
信号转导
遗传学
基因
转移性黑色素瘤
作者
Lorenza P. Ferretti,Flurina Böhi,Deena M. Leslie Pedrioli,Phil F. Cheng,E Ferrari,Petra Baumgaertner,Abdiel Alvarado-Diaz,Federica Sella,Alessandra Cereghetti,Patrick Turko,Roni H. G. Wright,Katrien De Bock,Daniel E. Speiser,Roberto Ferrari,Mitchell P. Levesque,Michael O. Hottiger
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2023-09-20
卷期号:83 (23): 3974-3988
被引量:17
标识
DOI:10.1158/0008-5472.can-23-0485
摘要
PARP inhibitors can overcome resistance to MAPK inhibitors by activating autophagic cell death and reversing phenotype switching, suggesting that this synergistic combination could help improve the prognosis of patients with melanoma.
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