二硒醚
对映体
试剂
化学
组合化学
氧化磷酸化
二苯基二硒醚
反应性(心理学)
过氧化氢
对映体过量
对映选择合成
有机化学
催化作用
硒
医学
生物化学
替代医学
病理
作者
Run Sun,Emilie Viaud,N. Rajesh,Jean-Valère Naubron,Nicolas Daugey,Thierry Buffeteau,Frédéric Castet,Patrick Y. Toullec,Stéphane Quideau,Philippe A. Peixoto
标识
DOI:10.1002/anie.202310436
摘要
The reactivity of novel chiral lactamide-substituted diselenide-based reagents under oxidative conditions was exploited to develop a metal-free method for the preparation of enantioenriched allenylamides from simple alkynes in good yields, and with enantiomeric excesses up to 99 %. The key of the success in this method is attributed to the hydrogen-bonded lactamide appendages that ensure configurational stability of chiral vinyl selenoxide intermediates for an optimal enantiotopic β-syn-elimination step.
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