抗原变异
生物
抗原
基因组
布氏锥虫
基因组组织
遗传学
基因
免疫系统
作者
Anna Barcons-Simon,Mark Carrington,T. Nicolai Siegel
出处
期刊:Nature microbiology
日期:2023-07-31
卷期号:8 (8): 1408-1418
标识
DOI:10.1038/s41564-023-01424-9
摘要
Antigenic variation as a strategy to evade the host adaptive immune response has evolved in divergent pathogens. Antigenic variation involves restricted, and often mutually exclusive, expression of dominant antigens and a periodic switch in antigen expression during infection. In eukaryotes, nuclear compartmentalization, including three-dimensional folding of the genome and physical separation of proteins in compartments or condensates, regulates mutually exclusive gene expression and chromosomal translocations. In this Review, we discuss the impact of nuclear organization on antigenic variation in the protozoan pathogens Trypanosoma brucei and Plasmodium falciparum. In particular, we highlight the relevance of nuclear organization in both mutually exclusive antigen expression and genome stability, which underlie antigenic variation. Antigenic variation is used by pathogens to evade the host immune system. This Review describes the impact of nuclear organization on antigenic variation in protozoan parasites.
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