潘特林
排泄系统
内分泌学
内科学
化学
平衡
钾
排泄
髓腔
肾脏生理学
分泌物
生物物理学
药物化学
肾
生物化学
生物
医学
运输机
肾功能
有机化学
基因
作者
Lama Al‐Qusairi,Mohammed Z. Ferdaus,Truyen D. Pham,Dimin Li,P. Richard Grimm,Ava M. Zapf,Delaney C Abood,Seyed Mohammad Ebrahim Tahaei,Eric Delpire,Susan M. Wall,Paul A. Welling
出处
期刊:American Journal of Physiology-renal Physiology
[American Physiological Society]
日期:2023-09-01
卷期号:325 (3): F377-F393
被引量:4
标识
DOI:10.1152/ajprenal.00193.2023
摘要
Dietary anions profoundly impact K + homeostasis. Here, we found that a K + -rich diet, containing [Formula: see text] as the counteranion, enhances the electrogenic K + excretory machinery, epithelial Na + channels, and renal outer medullary K + channels, much more than a high-KCl diet. It also uniquely induces KCC3a and pendrin, in B-intercalated cells, providing an electroneutral KHCO 3 secretion pathway. These findings reveal new K + balance mechanisms that drive adaption to alkaline and K + -rich foods, which should guide new treatment strategies for K + disorders.
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