再生医学
组织修复
细胞生物学
组织工程
干细胞
纳米技术
化学
计算生物学
生物
材料科学
遗传学
作者
Xiaohang Chen,Xiaohua Xing,Sheng-Yu Lin,Luqi Huang,Lei He,Yuchun Zou,Xuyang Zhang,Bogong Su,Youguang Lu,Dali Zheng
标识
DOI:10.1186/s12951-023-02193-7
摘要
Tissue damage and aging lead to dysfunction, disfigurement, and trauma, posing significant global challenges. Creating a regenerative microenvironment to resist external stimuli and induce stem cell differentiation is essential. Plant-derived nanovesicles (PDNVs) are naturally bioactive lipid bilayer nanovesicles that contain proteins, lipids, ribonucleic acid, and metabolites. They have shown potential in promoting cell growth, migration, and differentiation into various types of tissues. With immunomodulatory, microbiota regulatory, antioxidant, and anti-aging bioactivities, PDNVs are valuable in resisting external stimuli and facilitating tissue repair. The unique structure of PDNVs provides an optimal platform for drug encapsulation, and surface modifications enhance their stability and specificity. Moreover, by employing synergistic administration strategies, PDNVs can maximize their therapeutic potential. This review summarized the progress and prospects of PDNVs as regenerative tools, provided insights into their selection for repair activities based on existing studies, considered the key challenge for clinical application, and anticipated their continued prominent role in the field of biomedicine.
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