Hesperidin Alleviates Acute Necrotizing Pancreatitis by Activating SIRT1- Molecular Docking, Molecular Dynamics Simulation, and ExperimentalValidation

These findings indicate that hesperidin alleviates the severity of acute necrotizing pancreatitis by activating SIRT1, which may provide insight into the mechanisms of natural compounds in treating AP. Hesperidin has potential as a therapeutic agent for acute necrotizing pancreatitis and provides a new approach for novel therapeutic strategies.