分泌物
胰岛素
糖尿病
翻译后修饰
细胞生物学
功能(生物学)
生物
信号转导
内分泌学
生物化学
酶
作者
Chunhua Yang,Mengna Wei,Yanpu Zhao,Zhen Yang,Miao Song,Jia Mi,Xiaoyong Yang,Geng Tian
标识
DOI:10.3389/fcell.2023.1217189
摘要
Post-translational modification (PTM) has a significant impact on cellular signaling and function regulation. In pancreatic β cells, PTMs are involved in insulin secretion, cell development, and viability. The dysregulation of PTM in β cells is clinically associated with the development of diabetes mellitus. Here, we summarized current findings on major PTMs occurring in β cells and their roles in insulin secretion. Our work provides comprehensive insight into understanding the mechanisms of insulin secretion and potential therapeutic targets for diabetes from the perspective of protein PTMs.
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