纳米技术
聚合物
材料科学
表面改性
导电聚合物
离子键合
电子材料
电化学
桥(图论)
生物电子学
化学
生物传感器
复合材料
电极
有机化学
离子
物理化学
医学
内科学
作者
Sihao Qian,Horn-Bond Lin,Qichao Pan,Shuhua Zhang,Yunhua Zhang,Zhi Geng,Qing Wu,Yong He,Bo Zhu
标识
DOI:10.1016/j.bioactmat.2023.02.010
摘要
Conducting polymers offer attractive mixed ionic-electronic conductivity, tunable interfacial barrier with metal, tissue matchable softness, and versatile chemical functionalization, making them robust to bridge the gap between brain tissue and electronic circuits. This review focuses on chemically revised conducting polymers, combined with their superior and controllable electrochemical performance, to fabricate long-term bioelectronic implants, addressing chronic immune responses, weak neuron attraction, and long-term electrocommunication instability challenges. Moreover, the promising progress of zwitterionic conducting polymers in bioelectronic implants (≥4 weeks stable implantation) is highlighted, followed by a comment on their current evolution toward selective neural coupling and reimplantable function. Finally, a critical forward look at the future of zwitterionic conducting polymers for in vivo bioelectronic devices is provided.
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