自愈水凝胶
抗菌活性
生物相容性
伤口愈合
伤口敷料
纳米技术
生物医学工程
抗菌剂
化学
材料科学
抗生素
医学
细菌
高分子化学
外科
复合材料
生物
生物化学
冶金
遗传学
作者
Ben Jia,Guowei Li,Ertai Cao,Jinlong Luo,Xin Zhao,Heyuan Huang
标识
DOI:10.1016/j.mtbio.2023.100582
摘要
Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar to human soft tissue extracellular matrix, and tissue repair properties. In skin wound repair, hydrogels with antibacterial functions are especially suitable for dressing applications, so novel antibacterial hydrogel wound dressings have attracted widespread attention, including the design of components, optimization of preparation methods, strategies to reduce bacterial resistance, etc. In this review, we discuss the fabrication of antibacterial hydrogel wound dressings and the challenges associated with the crosslinking methods and chemistry of the materials. We have investigated the advantages and limitations (antibacterial effects and antibacterial mechanisms) of different antibacterial components in the hydrogels to achieve good antibacterial properties, and the response of hydrogels to stimuli such as light, sound, and electricity to reduce bacterial resistance. Conclusively, we provide a systematic summary of antibacterial hydrogel wound dressings findings (crosslinking methods, antibacterial components, antibacterial methods) and an outlook on long-lasting antibacterial effects, a broader antibacterial spectrum, diversified hydrogel forms, and the future development prospects of the field.
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