Extracellular Vesicles Identification Extracellular vesicles (EVs) are a potential cancer biomarker enclosing molecular information that hold great promise for early-stage diagnosis and monitoring of cancer. Novel adaptations of optical readouts integrate nanostructures to enhance the sensitivity of the detection of EVs. Furthermore, combining them with machine learning analysis can overcome common challenges in the study of EVs present in liquid biopsy samples. These topics are reviewed in article 2202123 by Sara Mahshid and co-workers. Cover image designed by Ella Maru Studio.