日本脑炎
黄病毒
抗病毒药物
重新调整用途
公共卫生
医学
药品
病毒学
药物重新定位
病毒
药物开发
脑炎
寨卡病毒
生物
重症监护医学
精神科
生态学
病理
作者
Jiao Guo,Yuan Mi,Yang Guo,Yang Bai,Meihua Wang,Wei Wang,Yang Wang
出处
期刊:Viruses
[MDPI AG]
日期:2024-01-28
卷期号:16 (2): 202-202
摘要
Japanese encephalitis virus (JEV) belongs to the Flaviviridae family and is a representative mosquito-borne flavivirus responsible for acute encephalitis and meningitis in humans. Despite the availability of vaccines, JEV remains a major public health threat with the potential to spread globally. According to the World Health Organization (WHO), there are an estimated 69,000 cases of JE each year, and this figure is probably an underestimate. The majority of JE victims are children in endemic areas, and almost half of the surviving patients have motor or cognitive sequelae. Thus, the absence of a clinically approved drug for the treatment of JE defines an urgent medical need. Recently, several promising and potential drug candidates were reported through drug repurposing studies, high-throughput drug library screening, and de novo design. This review focuses on the historical aspects of JEV, the biology of JEV replication, targets for therapeutic strategies, a target product profile, and drug development initiatives.
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