机制(生物学)
翻译(生物学)
核糖核酸
生物
疾病
肝病
细胞生物学
神经科学
计算生物学
生物信息学
基因
信使核糖核酸
医学
生物化学
病理
哲学
认识论
作者
Sheng Wang,Songsen Gao,Wufei Ye,Yueran Li,Jiajie Luan,Xiongwen Lv
标识
DOI:10.1016/j.biopha.2023.114669
摘要
N6-methyladenosine (m6A) modification, as one of the most common types of inner RNA modification in eukaryotes, plays a multifunctional role in normal and abnormal biological processes. This type of modification is modulated by m6A writer, eraser and reader, which in turn impact various processes of RNA metabolism, such as RNA processing, translation, nuclear export, localization and decay. The current academic view holds that m6A modification exerts a crucial role in the post-transcriptional modulation of gene expression, and is involved in multiple cellular functions, developmental and disease processes. However, the potential molecular mechanism and specific role of m6A modification in the development of liver disease have not been fully elucidated. In our review, we summarized the latest research progress on m6A modification in liver disease, and explored how these novel findings reshape our knowledge of m6A modulation of RNA metabolism. In addition, we also illustrated the effect of m6A on liver development and regeneration to prompt further exploration of the mechanism and role of m6A modification in liver physiology and pathology, providing new insights and references for the search of potential therapeutic targets for liver disease.
科研通智能强力驱动
Strongly Powered by AbleSci AI