Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis

In a recent publication in Nature, Xu et al. 1 Xu P. Liu Y. Liu C. Guey B. Li L. Melenec P. Ricci J. Ablasser A. The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation. Nature. 2024; 627: 873-879https://doi.org/10.1038/s41586-024-07112-w Crossref Scopus (3) Google Scholar discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis. In a recent publication in Nature, Xu et al. 1 Xu P. Liu Y. Liu C. Guey B. Li L. Melenec P. Ricci J. Ablasser A. The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation. Nature. 2024; 627: 873-879https://doi.org/10.1038/s41586-024-07112-w Crossref Scopus (3) Google Scholar discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis.