Recent advances in metalloporphyrin-catalyzed fluorinated carbene transfer reactions

Over the past two decades, metalloporphyrin-catalyzed fluorinated carbene transfer reactions have achieved remarkable progress in the field of organofluorine chemistry. This review summarizes the applications of metalloporphyrins in catalyzing the transfer of fluorinated carbenes, including trifluoromethylcarbene, difluoromethylcarbene, monofluorocarbene and difluorocarbene, reported since 2006. The catalysts exhibit excellent activity, substrate adaptability, and selectivity, while the novel carbene precursors, such as sulfonium salts and sulfonylhydrazones enhance operational safety and reaction efficiency. Overall, this review not only systematically examines the development of metalloporphyrin-catalyzed fluorinated carbene chemistry, but also provides valuable theoretical support and practical guidance for future advancements in organofluorine chemistry.