ATP酶
立体化学
抑制性突触后电位
化学
酶
结晶学
生物化学
生物
神经科学
作者
Wataru Yamawaki,Kuniaki Suzuki,Yuri Hase,Hiroshi Aoyama,Atsushi Nakayama,Makoto Sako,Mitsuhiro Arisawa
标识
DOI:10.1021/acs.jnatprod.5c00463
摘要
We have now successfully synthesized (±)-minimiflorin, known as a natural product with H+/K+-ATPase inhibitory activities, via two routes. Considering the structural similarity between H+/K+-ATPase and Na+/K+-ATPase, with 60% sequence homology, we measured the Na+/K+-ATPase inhibitory activities of our synthesized (±)-minimiflorin and found that it has Na+/K+-ATPase inhibitory activities.
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