沙粒病毒
病毒学
淋巴细胞性脉络膜脑膜炎
朱宁病毒
拉沙病毒
生物
病毒
病毒载体
免疫学
免疫系统
基因
遗传学
重组DNA
CD8型
作者
Qianqian Li,Weijin Huang,Youchun Wang
标识
DOI:10.1007/978-981-99-0113-5_15
摘要
Mammarenaviruses are classified into New World arenaviruses (NW) and Old World arenaviruses (OW). The OW arenaviruses include the first discovered mammarenavirus-lymphocytic choriomeningitis virus (LCMV) and the highly lethal Lassa virus (LASV). Mammarenaviruses are transmitted to human by rodents, resulting in severe acute infections and hemorrhagic fever. Pseudotyped viruses have been widely used as a tool in the study of mammarenaviruses. HIV-1, SIV, FIV-based lentiviral vectors, VSV-based vectors, MLV-based vectors, and reverse genetic approaches have been applied in the construction of pseudotyped mammarenaviruses. Pseudotyped mammarenaviruses are commonly used in receptor research, neutralizing antibody detection, inhibitor screening, viral virulence studies, functional analysis of N-linked glycans, and studies of viral infection, endocytosis, and fusion mechanisms.
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