纤溶
医学
纤维蛋白
静脉血栓形成
血栓形成
凝结
心肌梗塞
心脏病学
内科学
冲程(发动机)
免疫学
机械工程
工程类
作者
Vassilios Memtsas,Deepa R. J. Arachchillage,Diana A. Gorog
摘要
Diseases such as myocardial infarction, ischaemic stroke, peripheral vascular disease and venous thromboembolism are major contributors to morbidity and mortality. Procoagulant, anticoagulant and fibrinolytic pathways are finely regulated in healthy individuals and dysregulated procoagulant, anticoagulant and fibrinolytic pathways lead to arterial and venous thrombosis. In this review article, we discuss the (patho)physiological role and laboratory assessment of fibrin, factor XIII and endogenous fibrinolysis, which are key players in the terminal phase of the coagulation cascade and fibrinolysis. Finally, we present the most up-to-date evidence for their involvement in various disease states and assessment of cardiovascular risk.
科研通智能强力驱动
Strongly Powered by AbleSci AI