转录因子
生物
表观遗传学
祖细胞
基因
遗传学
抄写(语言学)
细胞生物学
细胞命运测定
干细胞
语言学
哲学
作者
Hiroyuki Hosokawa,Ellen V. Rothenberg
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2020-09-11
卷期号:21 (3): 162-176
被引量:147
标识
DOI:10.1038/s41577-020-00426-6
摘要
Recent evidence has elucidated how multipotent blood progenitors transform their identities in the thymus and undergo commitment to become T cells. Together with environmental signals, a core group of transcription factors have essential roles in this process by directly activating and repressing specific genes. Many of these transcription factors also function in later T cell development, but control different genes. Here, we review how these transcription factors work to change the activities of specific genomic loci during early intrathymic development to establish T cell lineage identity. We introduce the key regulators and highlight newly emergent insights into the rules that govern their actions. Whole-genome deep sequencing-based analysis has revealed unexpectedly rich relationships between inherited epigenetic states, transcription factor-DNA binding affinity thresholds and influences of given transcription factors on the activities of other factors in the same cells. Together, these mechanisms determine T cell identity and make the lineage choice irreversible.
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