雌激素
神经保护
雌激素受体
信号转导
阿尔茨海默病
神经科学
痴呆
医学
雌激素受体α
疾病
内科学
内分泌学
生物
生物信息学
细胞生物学
乳腺癌
癌症
作者
Sahab Uddin,Motiar Rahman,Md. Jakaria,Md. Sohanur Rahman,Sarwar Hossain,Ariful Islam,Mohiuddin Ahmed,Bijo Mathew,Ulfat M. Omar,George E. Barreto,Ghulam Md Ashraf
标识
DOI:10.1007/s12035-020-01911-8
摘要
Estrogens play a crucial physiological function in the brain; however, debates exist concerning the role of estrogens in Alzheimer’s disease (AD). Women during pre-, peri-, or menopause periods are more susceptible for developing AD, suggesting the connection of sex factors and a decreased estrogen signaling in AD pathogenesis. Yet, the underlying mechanism of estrogen-mediated neuroprotection is unclarified and is complicated by the existence of estrogen-related factors. Consequently, a deeper analysis of estrogen receptor (ER) expression and estrogen-metabolizing enzymes could interpret the importance of estrogen in age-linked cognitive alterations. Previous studies propose that hormone replacement therapy may attenuate AD onset in postmenopausal women, demonstrating that estrogen signaling is important for the development and progression of AD. For example, ERα exerts neuroprotection against AD by maintaining intracellular signaling cascades and study reported reduced expression of ERα in hippocampal neurons of AD patients. Similarly, reduced expression of ERβ in female AD patients has been associated with abnormal function in mitochondria and improved markers of oxidative stress. In this review, we discuss the critical interaction between estrogen signaling and AD. Moreover, we highlight the potential of targeting estrogen-related signaling for therapeutic intervention in AD.
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